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As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures

Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo

Enhanced Recovery Sustained GH action means tissue repair benefits are present around the clock not just in the hours after injection

doi: 10.1016/j.cmet.2020.10.011 7 DixonSJStockwellBR